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KMID : 0882420080750040463
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Korean Journal of Medicine
2008 Volume.75 No. 4 p.463 ~ p.466
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A case of Sweet syndrome involving the central nervous system
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Jung Hyun-Young
Kim Soo-Kyung
Park Keun-Woo
Park Chul-Yeon
Chung Seung-Hie
Park Sung-Hoon
Choe Jung-Yoon
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Abstract
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Sweet syndrome is an unusual disease characterized by the sudden onset of fever, leukocytosis, and painful
erythematous plaques, and the dermal infiltration of neutrophils at the site of skin lesions. Although Sweet syndrome can
also present with extra-cutaneous manifestations, involvement of the central nervous system (CNS) is rarely reported.
We describe a case of Sweet syndrome involving the CNS in a 46-year-old male with a disturbance of consciousness
following fever and erythematous skin plaques in the extremities. Cerebrospinal fluid examination disclosed neutrophilic
pleocytosis without decreased glucose and protein levels. HLA typing showed B54, which is frequently seen in Sweet
syndrome. Brain magnetic resonance imaging showed abnormal signal intensity lesions in the left temporal lobe. Skin
biopsy revealed a dense dermal infiltration of neutrophils, which is compatible with Sweet syndrome. The confused
mentality, fever, and erythematous skin plaques resolved after the administration of systemic corticosteroids.
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KEYWORD
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Sweet syndrome, Central nervous system
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